Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid driving or hazardous activity until you know how cyclobenzaprine will affect you. It may not be safe to breast-feed while using this medicine. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine.

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Call your doctor for medical advice about side effects. Flexeril is used together with rest and physical therapy to treat skeletal muscle conditions such as pain, injury, or spasms. You may report side effects to FDA at FDA-1088 or at /medwatch. The most common adverse reactions to cyclobenzaprine are somnolence, dry mucous membranes, dizziness, and confusion. Less commonly, tachycardia, dysarthria, disorientation, and hallucinations have been reported [2]. Dogs can take muscle relaxers such as Flexeril for pain relief.

FDA Drug Information

In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Although rare, deaths may occur from overdosage with FLEXERIL.

• However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.
• MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
• At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats.
• It belongs to a group of medications called muscle relaxants.
• Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models.
• These may be symptoms of a serious condition called serotonin syndrome.

It is unknown if Flexeril passes into breast milk or if it could harm a nursing baby. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. HealthLinkBC Files are easy-to-understand fact sheets on a range of public health and safety topics including disease prevention and immunizations.

Muscle Spasm

Do not drive or operate machinery until you know howFlexeril affects you. Common side effects of Flexeril include dry mouth, fatigue, and upset stomach. A long-acting formulation of cyclobenzaprine has been introduced and is believed by some clinicians to have a lower side effect profile than the immediate-release formulation of this drug. It blocks the pathways of neurotransmitters that signal pain and diminishes the sensations of pain. It is also much more addictive than conventional painkillers or Over-the-counter (OTC) Non-Steroidal Anti-inflammatory Drugs (NSAIDs) available in the market that are pain relievers in action.

It is not known whether cyclobenzaprine will harm an unborn baby. Flexeril may also be used for purposes not listed in this medication guide.

Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.

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Give your care team a list of all medications you use. Your care team will tell you how much medication to take. Call emergency for help if you have problems breathing or unusual sleepiness. Ask your healthcare professional how you should dispose of any medicine you do not use.

It is also possible for serious cyclobenzaprine side effects to occur, like seizures, heart arrhythmias, heart attack, or stroke. These are more likely to occur when a person has too much cyclobenzaprine in their system, for instance, if their prescription dose is too high or if they are misusing the drug. Sometimes, muscle relaxants like cyclobenzaprine are used “off-label” flexeril.live to treat conditions they’re not approved for, such as fibromyalgia. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.

Recent Activity

Flexeril produces a variety of anticholinergic effects in high doses, altering the activity of brain neurotransmitters. Additionally, Flexeril users may experience mild withdrawal symptoms if the drug is used chronically in high doses. Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable.